Difference Between Lock And Key Model And Induced Fit Model Of Enzyme Action

The induced fit model is an elaboration on the basic idea of the lock and key model.

Difference between lock and key model and induced fit model of enzyme action.

They are important in describing how enzymes increase the rate of a biological reaction through catalysis. The lock and key model suggests that the substrate is completely complementary in shape to the active site so that it fits in perfectly i e. Two main theories are used to explain how enzyme substrate complexes form. Similarities between induced fit and lock and key model.

Both models depend on the degree of precise binding of the substrate to the active site of the enzyme. Daniel e koshland formulated this hypothesis in 1959. They are lock and key theory and induced fit theory. Instead the substrate interacts with the active site and both change their shape to fit together.

Whereas in the lock and key theory the substrate and the active site of the enzyme are complementary in shape at the beginning. The key difference between induced fit and lock and key is that in induced fit theory the binding of the substrate with the active site of the enzyme induces the modification of the shape of the active site into the complementary shape of the substrate. Induced fit and lock and key are the two models which describe the mechanism of action of the enzyme. There is no change in shape of the active site.

In this theory the substrate fits into an active site like a key into a lock. The lock and key model and the induced fit hypothesis are two potential models for how substrates may bind in the active site of an enzyme. In this model though the key and the enzyme active site do not fit perfectly together. The binding of the substrate molecule to the enzyme molecule induces to modify the shape of the active site so that it becomes complementary to the substrate molecule.